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Mentor(s): Anna Radke, Ph.D.

Alcohol Use Disorder (AUD) shows clear sex differences, with men typically exhibiting higher rates, while women may escalate use more rapidly. One potential biological contributor is Gprasp1, a gene that escapes X-chromosome inactivation and may influence alcohol-related behaviors. This study uses genetic knockdown of Gprasp1 in the medial prefrontal cortex (mPFC) of male and female mice to assess its role in alcohol consumption. We hypothesize that Gprasp1 knockdown will reduce drinking, particularly in males, providing insight into sex-specific mechanisms of AUD.